Radiesse is the brand name of a substance called calcium hydroxyapatite. In use in other areas of medicine and surgery for over 20 years, Radiesse is now available for hand rejuvenation. It is mixed with local anesthetic and injected beneath the skin of the back, or dorsum, of the hand. Radiesse fills in the hollows between tendons and covers up veins. Only Radiesse and fat grafting are indicated for rejuvenation of the dorsum of the hand.